Survivin expression in the bone marrow of patients with severe congenital neutropenia
نویسندگان
چکیده
منابع مشابه
Granulopoiesis in severe congenital neutropenia.
The pathogenesis of the granulopoietic failure in three children with severe congenital neutropenia was studied. Mature neutrophils were absent from both peripheral blood and bone marrow. Assay of bone marrow granulocyte colony-forming cells (CFU-C) in a methylcellulose tissue culture system using colony-stimulating activity (CSA) from peripheral blood leukocytes demonstrated normal or increase...
متن کاملExpression of granule-associated proteins in neutrophils from patients with severe congenital neutropenia.
In a recent publication in Blood, Donini et al1 conclude that granulocyte colony-stimulating factor (G-CSF) treatment of severe congenital neutropenia (SCN) results in abnormal expression of granule-associated proteins. We have previously published this concept,2 and showed that neutrophils from patients with SCN lack the antimicrobial peptide LL-37 and have reduced levels of defensins (HNP1–3)...
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Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...
متن کاملVitamin D3 induces pro-LL-37 expression in myeloid precursors from patients with severe congenital neutropenia.
The innate immune system produces a number of effector molecules that are important for protection against bacterial infections. Neutrophils and antimicrobial peptides are major components of innate defense with the capacity of rapid bacterial killing. Patients with severe congenital neutropenia (SCN) experience recurrent and chronic infections despite recombinant G-CSF-mobilized neutrophils. W...
متن کاملprevention and control of infections in patients with severe congenital neutropenia; a follow up study
severe congenital neutropenia is one of primary immunodeficiency disorders that characterized by severe neutropenia and is associated with severe systemic bacterial infections from early infancy. granulocyte colony stimulating factor (gcsf) is clinically used as a treatment for congenital and acquired neutropenia. the aim of this study was evaluation of gcsf (pd- grastim) in treatme...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2008
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2008.258